论文部分内容阅读
在乙醇-水混合体系中,以氨水为沉淀剂共沉淀合成了甲氨蝶呤/层状双金属氢氧化物(MTX/LDH)纳米复合物,首次采用控制沉淀剂滴加速率的方式来调控其粒径.利用X-射线衍射(XRD)、透射电镜(TEM)和红外光谱(FT-IR)等表征手段,对其结构及形貌进行了表征.研究表明:MTX分子以单层倾斜方式插入LDH层间,随着滴加速率不同,MTX在层间的倾斜角度发生了变化;沉淀剂滴加速率对产物的结晶度、粒径和层间排列方式都有影响,当沉淀剂滴加速率为0.100 mL/s时,得到的MTX/LDH纳米复合物的结晶度最高,粒径最大.在磷酸缓冲液中考察了不同粒径MTX/LDH纳米复合物的缓释性能,结果表明:小粒径的MTX/LDH纳米复合物的载药量要高于大粒径的;当MTX阴离子在层间的倾斜角度相似时,粒径小的粒子释放速率较慢,缓释效果优于粒径大的.尤为重要的是我们探索出一条保证复合物阴离子在层间的倾斜角度相似的情况下,制备不同粒径纳米复合物的新途径.
Methotrexate / layered double hydroxide (MTX / LDH) nanocomposites were synthesized by coprecipitation with ammonia water as a precipitating agent in the ethanol-water mixed system. For the first time, the concentration of MTX / The size and morphology of the particles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FT-IR) The intercalation angle of MTX changed with the different dropping rates. The dropping rate of precipitating agent affected the crystallinity, particle size and interlayer arrangement of LDH. When the dropping rate of precipitating agent The MTX / LDH nanocomposites obtained had the highest crystallinity and the largest particle size at a rate of 0.100 mL / s.The sustained release properties of MTX / LDH nanocomposites with different particle sizes were examined in phosphate buffer solution. The results showed that the small The drug loading of MTX / LDH nanocomposites with larger particle size was higher than that with large particle size. When the MTX anions were inclined at different layers, the release rate of particles with small particle size was slower and the release rate was better than particle size Especially important is that we have explored a way to ensure that the anions in the composite have an oblique angle between the layers A similar case, new ways of different sizes nanocomposite prepared.