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目的运用MR扩散加权成像对不同类型良性前列腺增生的ADC值进行定量分析,并与前列腺癌ADC值进行比较。方法17例行经尿道前列腺电切术的良性前列腺增生患者,在术前3个月内均进行了前列腺DWI检查。采用单次激发EPI序列,b值为0 s/mm2和800 s/mm2,电切术后对标本进行了组织学分类,将增生组织分为腺体型增生和间质型增生,并分别测量其ADC值。另外还选取了15例穿刺活检证实的前列腺癌病人,测量其癌区的ADC值。对所得3组数值进行统计学分析。结果腺体型增生、间质型增生、前列腺癌的ADC值分别为(1.80±0.20)×10-3mm2/s、(1.56±0.18)×10-3mm2/s、(1.27±0.21)×10-3mm2/s,3组间具有统计学差异(F=47.366,P<0.01,one-way ANOVA),两两比较也具有统计学意义(P值均<0.01)。腺体增生和间质增生间有62%的ADC值重叠,腺体增生和癌之间有22%的ADC值重叠,间质增生与癌之间有57%的ADC值重叠。结论用ADC值可以定量评价不同类型的良性前列腺增生,增生与前列腺癌的ADC值有统计学差异,但存在部分重叠,以间质型增生重叠较明显。
Objective To quantitatively analyze the ADC value of different types of benign prostatic hyperplasia by using MR diffusion weighted imaging and to compare with ADC value of prostate cancer. Methods Seventeen patients underwent transurethral resection of prostate benign prostatic hyperplasia (BPH) underwent preoperative DWI within 3 months before operation. The single EPI sequence was used and the b values were 0 s / mm2 and 800 s / mm2. The specimens were histologically sorted after the resection, and the hyperplasia tissues were divided into glandular hyperplasia and interstitial hyperplasia. The ADC value. In addition, 15 cases of prostate cancer patients confirmed by biopsy were selected to measure the ADC value of their cancer area. The three groups of values obtained for statistical analysis. Results The ADC values of glandular hyperplasia, interstitial hyperplasia and prostate cancer were (1.80 ± 0.20) × 10-3mm2 / s, (1.56 ± 0.18) × 10-3mm2 / s and (1.27 ± 0.21) × 10- 3mm2 / s. There was a significant difference among the 3 groups (F = 47.366, P <0.01, one-way ANOVA), and any pairwise comparison was statistically significant (P <0.01). 62% of ADC values overlap between glandular hyperplasia and interstitial hyperplasia, 22% of ADC values overlap between glandular hyperplasia and carcinoma, and 57% overlap between stromal hyperplasia and carcinoma. Conclusion ADC value can be used to quantitatively evaluate different types of benign prostatic hyperplasia. The ADC value of hyperplasia and prostate cancer are statistically different, but there is a partial overlap and the overlap of interstitial hyperplasia is obvious.