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目的研究海洋来源真菌Hypocrea virens发酵产物的化学成分。方法采用硅胶柱色谱和Sephadex LH-20凝胶柱色谱等方法进行分离纯化,通过理化性质和波谱数据鉴定化合物的结构。结果分离得到7个化合物,结构鉴定为异光黄素(1)、1-乙酰基-β-卡波林(2)、苯并噻唑啉-2-硫酮(3)、2,2’-二硫化二苯并噻唑(4)、吡咯并哌嗪-2,5-二酮(5)、腺苷(6)、2-乙酰胺基-2-去氧-α-D-吡喃葡萄糖(7)。结论化合物1～5均为首次从该属真菌中分离得到,化合物6、7为首次从该种真菌中分离得到。
Objective To study the chemical constituents of the fermentation products of marine fungi Hypocrea virens. Methods The compounds were isolated and purified by silica gel column chromatography and Sephadex LH-20 gel column chromatography. The structures of the compounds were identified by their physicochemical properties and spectral data. As a result, seven compounds were isolated and identified as isoflavin (1), 1-acetyl-β-carbopol (2), benzothiazoline-2-thione (3) Dibenzothiazolyl disulfide (4), pyrrolopiperazine-2,5-dione (5), adenosine (6), 2-acetamido-2-deoxy-α-D-glucopyranose 7). CONCLUSION Compounds 1 to 5 were isolated from this genus for the first time. Compounds 6 and 7 were isolated from this fungus for the first time.