论文部分内容阅读
目的分析比较联合用药与单纯甲氨蝶呤治疗宫外孕的临床疗效。方法选取2009年10月至2011年10月收治的符合保守治疗标准的宫外孕患者60例,随机分为联合组30例和对照组30例。联合组在肌肉注射甲氨蝶呤50mg,1次/d的基础上口服米非司酮50mg,2次/d;对照组仅应用甲氨蝶呤50mg肌肉注射,1次/d。分析比较两组患者接受治疗5d后的治愈率及不良反应发生情况。结果治疗5d后,联合组治愈率96.6%显著高于对照组治愈率75.0%(P<0.05);两组患者不良反应主要为胃肠不适、头晕、口腔溃疡、皮疹、肝功能异常及白细胞下降,反应较轻且经处理后均消失,联合组不良反应发生率24.1%与对照组不良反应发生率35.7%无明显差异(P>0.05)。结论联合用药治疗宫外孕疗效好于单纯甲氨蝶呤治疗,具有治愈率高、不良反应小的优点,值得临床推广应用。
Objective To compare the clinical efficacy of combination therapy with methotrexate alone in the treatment of ectopic pregnancy. Methods Sixty patients with ectopic pregnancy who met the conservative treatment criteria from October 2009 to October 2011 were randomly divided into 30 cases in combination group and 30 cases in control group. The combination group received intramuscular methotrexate 50mg, 1 / d on the basis of oral mifepristone 50mg, 2 times / d; control group only methotrexate 50mg intramuscular injection, 1 / d. Analysis and comparison of two groups of patients receiving treatment 5d after the cure rate and adverse reactions. Results After 5 days of treatment, the cure rate of the combined group was significantly higher than that of the control group (96.6% vs 75.0%, P <0.05). The adverse reactions in the two groups were gastrointestinal discomfort, dizziness, oral ulcer, rash, liver dysfunction and leukopenia , The reaction was mild and disappeared after treatment. The incidence of adverse reactions in the combined group was 24.1% and 35.7% in the control group. There was no significant difference (P> 0.05). Conclusions Combination therapy is more effective than methotrexate in the treatment of ectopic pregnancy. It has the advantages of high cure rate and small adverse reactions, which is worthy of clinical application.