论文部分内容阅读
本文报告在我国海南岛的抗氯喹疟疾流行区,用青蒿素水混悬注射剂一次肌注500mg,同时顿服周效磺胺1.000mg、乙氨嘧啶70mg和伯喹30mg的方法(以下简称青周乙伯一次疗法),治疗60例恶性疟患者的研究结果:平均体温恢复正常时间为32.84±2.22小时(50例);平均无性体原虫转阴时间为41.63±2.05小时(60例);平均配子体原虫消失时间为3.3±0.6天(22例);随访观察至用药后28天(58例)和60天(52例)均未发现复燃病例,根治率100%。药后付反应轻微,未发现有明显毒性。同期用青蒿素水混悬注射剂1,200mg分两天肌注;周效磺胺1,000毫克+乙氨嘧啶70mg+伯喹30mg一次顿服;氯喹标准剂量1,500mg,三天分服等三种方案对照比较,在体温恢复正常和无性体原虫转阴时间方面,除单用
This article reports the anti-chloroquine malaria endemic area in Hainan Island of our country with an intramuscular injection of 500 mg of the artemisinin-water suspension injection and a daily treatment of 1.000 mg of sulfasalazine, 70 mg of pyrimethamine and 30 mg of primaquine (hereinafter referred to as Qing Zhou Bibo A treatment), 60 cases of falciparum malaria patients: the average time to normal body temperature recovery was 32.84 ± 2.22 hours (50 cases); the average time of asexual protozoa negative was 41.63 ± 2.05 hours (60 cases); the average gametophyte disappeared The time was 3.3 ± 0.6 days (22 cases). No recurrence was found after 28 days (58 cases) and 60 days (52 cases) after follow-up, and the cure rate was 100%. Post-drug response minor, did not find significant toxicity. Simultaneous use of artemisinin water suspension injection 1,200mg intramuscular injection of two days; potent sulfamethoxazole 1,000 mg + 70 mg of pyrimethamine + primaquine 30mg once Dayton clothing; chloroquine standard dose of 1,500 mg, three days of service and other three programs comparison , In the body temperature returned to normal and asexual protozoa negative time, except for single use