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目的:探讨NOS及NO在分泌性中耳炎(SOM)所致感音神经性聋(SNHL)中的作用。方法:治疗前分别抽取16例伴有SNHL的SOM患者(A组)及16例不伴有SNHL的SOM患者(B组)的中耳积液,检测两组中耳积液内NOS活性和NO含量。结果:A组中耳积液内NO含量(181.19±44.31)μmol/L明显高于B组(137.00±40.67)μmol/L(P<0.01),A组中耳积液内NOS活性(97.69±29.62)U也明显高于B组(75.50±26.99)U(P<0.05)。结论:NO可能通过直接损伤和与其他炎症递质共同作用增强局部炎症反应,在SOM所致的SNHL过程中发挥重要作用。
Objective: To investigate the role of NOS and NO in sensorineural hearing loss (SNHL) induced by secretory otitis media (SOM). Methods: Twenty - six patients with SOM accompanied with SNHL (group A) and 16 patients with SOM without SNHL (group B) were selected for the treatment of middle ear fluid before treatment. The activity of NOS and NO content. Results: The content of NO in middle ear effusion of group A was significantly higher than that of group B (181.19 ± 44.31) μmol / L (137.00 ± 40.67) μmol / L (P <0.01) 29.62) U was also significantly higher than that of group B (75.50 ± 26.99) U (P <0.05). CONCLUSIONS: NO may enhance the local inflammatory response through direct injury and other inflammatory mediators, playing an important role in SOM-induced SNHL.