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1.引言近十年来,冠状血管扩张剂在综合治疗局部缺血性心脏病(IHD)中已失去其领导地位。这是由于对冠状疾患病因知识的增加和测定IHD药物治疗机理方面有了新的实验和临床资料的结果。慢性IHD的基本病因是心脏供氧和需氧之间的平衡失调。以往对IHD最有效治疗是使用增加总冠脉血流量的药物,但新的实验和临床均证明了在急、慢性心肌局部缺血情况下,血液动力学发生了变化。因此对早先应用的IHD有效药物机理和治疗途径作了修正。 2.决定IHD发生的因素冠心病发生的三个重要因素是:(1)由于
1. Introduction Coronary vasodilators have lost their leadership in the comprehensive treatment of ischemic heart disease (IHD) in the last decade. This is due to the new experimental and clinical data on the knowledge of the etiology of coronary disease and on the mechanism of IHD drug therapy. The underlying cause of chronic IHD is the imbalance of heart and oxygen supply. In the past, the most effective treatment for IHD was to use drugs that increased total coronary blood flow, but new experiments and clinics have shown hemodynamic changes in acute and chronic myocardial ischemia. Thus, the previously validated IHD pharmacological mechanisms and therapies were modified. 2. Factors that determine the occurrence of IHD Three important factors in the occurrence of coronary heart disease are: (1) Because