Association of H3K4me3 and CBX7 Levels to the Down-Regulation of <i>GKN</i&

• 作 者: Chiara Stella Di Stadio Filome
• 机 构: DepartmentofMolecularMedicineandMedicalBiotechnology,DepartmentofSurgery,CEINGE
• 出 处: 生物科学与医学(英文)
• 发表日期: 2019年5期
• 关键词: CBX7 Gastrokine 1 Gastric Cancer EPIGENETICS H3K4 Methylation CBX7 Gastrokine 1

Gastrokine 1 (GKN1) is a highly secreted gastric mucosal protein in normal individuals but strongly down-regulated or totally absent in gastric cancer subjects. An epigenetic mechanism might be responsible for GKN1 gene silencing probably through the acti