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目的以24h动态血压监测评价替米沙坦治疗轻、中度原发性高血压患者的疗效。方法选择30例轻中度高血压患者,予以替米沙坦80mg/d治疗8周,分别于治疗前后行24h动态血压监测并计算其谷峰比值、平滑指数后进行比较分析。结果治疗8周后24h平均收缩压、舒张压;日间平均收缩压、舒张压;夜间平均收缩压、舒张压与治疗前比较均有显著性降低(P<0.01),收缩压、舒张压负荷也有显著降低(P<0.01)。收缩压谷峰比值为63.2%,舒张压谷峰比值65.8%,收缩压平滑指数为(1.08±0.34),舒张压平滑指数为(1.12±0.23)。结论替米沙坦具有良好的降压效果及满意的谷峰比值、平滑指数,临床应用安全。
Objective To evaluate the effect of telmisartan on patients with mild to moderate essential hypertension by ambulatory blood pressure monitoring 24h. Methods 30 patients with mild to moderate hypertension were treated with telmisartan 80 mg / d for 8 weeks. The ambulatory blood pressure monitoring was performed 24 hours before and after treatment, and the ratio of trough to peak was calculated. The smoothness index was compared and analyzed. Results Mean systolic blood pressure and diastolic blood pressure at 24 weeks after treatment were significantly lower than those before treatment (P <0.01). Systolic blood pressure, diastolic blood pressure There was also a significant reduction (P <0.01). Systolic blood pressure trough peak ratio was 63.2%, diastolic valleys peak-to-peak ratio 65.8%, systolic pressure smoothness index (1.08 ± 0.34), diastolic pressure smoothness index was (1.12 ± 0.23). Conclusion Telmisartan has a good antihypertensive effect and satisfactory peak to peak ratio, smoothness index, clinical application of safety.