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用鸡急性血源性骨髓炎模型进行4周药物治疗对照研究.105只鸡,分7组,每组15只鸡.有①正常组对照,②实验对照,③青霉素+庆大霉素,④青霉素+庆大霉素+阿斯匹林,⑤邻氯青霉素,⑥短疗程邻氯青霉素(2周),⑦邻氯青霉素延迟48小时治疗.结果发现目前临床常用的青霉素+庆大霉素治疗由耐青霉素金葡菌引起的急性血源性骨髓炎效果并不理想,而邻氯青霉素疗效甚好.实验证明抗菌素必须尽早使用,延迟治疗则疗效下降.邻氯青霉素治疗4周或2周,结果一样满意,支持抗菌素疗程不必过长的新观点.新近观点还认为前列腺素对急性骨髓炎的发生发展起重要作用,但本文实验未能显示阿斯匹林有辅助治疗效用.
A four-week drug treatment and control study of acute hematogenous chicken osteomyelitis model was conducted in 105 chickens divided into 7 groups of 15 chickens each with ① normal control group, ② experimental control group, ③ penicillin + gentamicin group, ④ Penicillin + gentamicin + aspirin, ⑤ o-chloromycetin, ⑥ short course of o -chlorophencin (2 weeks), ⑦ chloramphenicol delayed 48 hours of treatment. The results found that the current clinical penicillin + gentamicin treatment Acute blood-borne osteomyelitis caused by penicillin-resistant Staphylococcus aureus is not very effective, but the effect of cloxacillin is very good.Experimental results show that antibiotics must be used as soon as possible and the curative effect of delayed treatment declines.Chlorphenacyline treatment for 4 or 2 weeks, The results are equally satisfactory, supporting the new viewpoints that antibiotics do not have to be overly prolonged.New viewpoints are also considered prostaglandins play an important role in the occurrence and development of acute osteomyelitis, but this experiment failed to show aspirin adjuvant therapy.