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目的研究日本血吸虫单克隆抗独特型抗体ＮＰ３０对虫卵肉芽肿的影响。方法 ＮＰ３０腹腔注射主动免疫ＩＣＲ小鼠，对照组腹腔注射ＳＰ２／０腹水，分别在尾蚴攻击感染后第４、８、１２、１６、２０、２４周处死，观察和比较肝内虫卵肉芽肿的形成和演变。应用计算机图像分析技术，测量虫卵肉芽肿大小。结果尾蚴攻击感染第 １２周以后， ＮＰ３０免疫组虫卵肉芽肿的直径明显低于 ＳＰ２／０对照组，虫卵肉芽肿的演变时相提前，并出现２种特殊类型的肉芽肿。结论ＮＰ３０能减轻日本血吸虫对宿主造成的免疫病理损害。
Objective To study the effect of the monoclonal anti-idiotypic antibody NP30 of Schistosoma japonicum on granuloma of the egg. Methods IC50 mice immunized by intraperitoneal injection of NP30 were given intraperitoneal injection of SP2 / 0 ascites. The mice were sacrificed on the 4th, 8th, 12th, 16th, 20th, 20th and 24th weeks after infection with cercariae respectively. The intrahepatic egg granuloma was observed and compared Formation and evolution. Application of computer image analysis technology, measurement of egg granuloma size. Results After the 12th week of cercariae challenge infection, the diameter of NP30 immunized group was significantly lower than that of the SP2 / 0 control group. The development of ovarian granuloma was advanced and two specific types of granulomas were found. Conclusion NP30 can reduce the immune pathological damage caused by Schistosoma japonicum to the host.