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目的探讨肺透明细胞肿瘤的临床病理学特征、鉴别诊断和预后。方法报道1例肺透明细胞肿瘤的临床及影像学资料,行HE及免疫组化染色,分析其临床、影像、病理学特征及免疫组化特点,并复习相关文献。结果患者查体胸透时偶然发现肺肿物,直径4.5 cm,无临床症状,体格检查和生化指标未见异常。大体见圆形结节一个,边界清楚,切面淡红色,质较软、细腻。镜下肿瘤由一致的胞质丰富透明或略嗜酸的圆形、多边形细胞组成,细胞界限清楚,围以薄壁的血管和血窦样腔隙。免疫组化示肿瘤细胞HMB45(+),CK、S-100、Syn、NSE和CD56(-);肿瘤细胞间薄壁血管CD34(+)。结论肺透明细胞肿瘤是一种罕见的良性肿瘤,男女发病无明显差异,患者多无临床症状,完整切除肿瘤即可治愈。
Objective To investigate the clinicopathological characteristics, differential diagnosis and prognosis of clear cell lung tumor. Methods The clinical and imaging data of 1 case of clear cell lung tumor were reported. HE and immunohistochemical staining were used to analyze the clinical, imaging, pathological features and immunohistochemical characteristics of the tumor. The related literatures were reviewed. Results When the patient was diagnosed with chest and thorax, lung tumor was found by accident, with a diameter of 4.5 cm. There was no clinical symptom, no abnormal physical examination and biochemical indexes. Generally see a circular nodule, a clear boundary, section pink, soft quality, delicate. Microscopic tumor by a consistent cytoplasm rich transparent or slightly acidic orbicular, polygonal cells, clear cell boundaries, surrounded by thin-walled blood vessels and sinusoids like lacunar. Immunohistochemistry showed that the tumor cells HMB45 (+), CK, S-100, Syn, NSE and CD56 (-); Conclusions Lung clear cell tumor is a rare benign tumor. There is no obvious difference between male and female patients. Most of the patients have no clinical symptoms and can be cured by complete resection of the tumor.