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目的探讨系统性红斑狼疮(SLE)患者尿中N-乙酰-β-氨基葡萄糖苷酶(NAG)水平及其临床意义。方法根据尿微量蛋白结果将65例SLE患者分为单纯肾小管受累组(n=30)和肾小管与肾小球均受累组(n=35)。21例健康体检者作为对照组。散射比浊法和比色法检测尿中NAG水平。结果组间比较显示:单纯肾小管受累组和肾小管与肾小球均受累组的尿NAG水平均显著高于对照组(P<0.05),而单纯肾小管受累组和肾小管与肾小球均受累组的尿NAG水平无明显差异(P>0.05)。65例SLE患者尿NAG与尿β2-微球蛋白呈显著的正相关性(r=0.96,P<0.05)。结论 SLE患者的尿检结果提示肾小管的病变可单独存在,而肾小球病变与肾小管病变同时存在。狼疮肾炎患者尿NAG水平显著增高,且与肾小管病变密切相关。
Objective To investigate the urinary N-acetyl-β-glucosaminidase (NAG) in patients with systemic lupus erythematosus (SLE) and its clinical significance. Methods According to the results of urinary microalbuminuria, 65 SLE patients were divided into simple renal tubular involvement group (n = 30) and tubular and glomerular involvement group (n = 35). Twenty-one healthy subjects were used as control group. Nephelometry and colorimetric assay for urinary NAG levels. Results Comparisons between groups showed that the levels of urinary NAG in tubules and glomerulus groups were significantly higher than those in control group (P <0.05), while tubules and glomeruli There was no significant difference in urinary NAG levels between the two groups (P> 0.05). There was a significant positive correlation between urine NAG and urine β2-microglobulin in 65 SLE patients (r = 0.96, P <0.05). Conclusion The urinalysis results of patients with SLE suggest that renal tubular lesions may exist alone, while glomerular lesions and tubular lesions exist. Patients with lupus nephritis urinary NAG levels were significantly higher, and closely related to renal tubular lesions.