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应用硝苯啶的钙通道阻滞原理,可以降低食管下端括约肌(LES)的压力。本文采用舌下含服硝苯啶治疗食管贲门失弛缓的双盲对照交叉试验。食管贲门失弛缓这种功能障碍的治疗依赖于降低LES压力。10例病人接受本试验。应用测压计测定LES压力,并逐日详细记录。用固体食物放射性核素法,测定食管排空率。在餐前应用硝苯啶10～
Application of nifedipine calcium channel blockage principle, can reduce the pressure of the lower esophageal sphincter (LES). In this paper, the sublingual nifedipine treatment of esophageal achalasia in a double-blind controlled cross-test. The treatment of dysfunction of the esophagus and cardia depends on the reduction of LES stress. Ten patients received the test. LES pressure was measured using a manometer and detailed daily. Using solid food radionuclide method, esophageal emptying rate was measured. Nifedipine 10 ~ before meals