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目的:探讨血清抵抗素、肿瘤坏死因子-α(TNF-α)水平对评价高原地区2型糖尿病(T2DM)患者血管内皮功能紊乱的意义。方法:选取高原地区T2DM患者60例,以60例健康人为对照组。测定血清抵抗素、TNF-α、一氧化氮(NO)、血管性血友病因子(vWF)、C反应蛋白(CRP)水平,进行比较研究。结果:高原地区T2DM患者血清抵抗素、TNF-α、vWF、CRP水平均高于正常对照组(均P<0.05);NO低于正常对照组(P<0.01)。T2DM组抵抗素与TNF-α、vWF、CRP呈正相关(r=0.47,r=0.32,r=0.42;均P<0.05);TNF-α与vWF、CRP亦呈正相关(r=0.30,P<0.05;r=0.42,P<0.01)。抵抗素、TNF-α与NO呈负相关(r=-0.47,r=-0.34;P<0.01)。结论:高原地区T2DM患者血清抵抗素、TNF-α水平增高,且与血管内皮功能相关指标呈正或负相关,提示血清抵抗素、TNF-α可能与T2DM血管并发症的发生有关,是预测高原地区T2DM患者血管并发症的有价值的指标。
Objective: To investigate the significance of serum resistin and tumor necrosis factor-α (TNF-α) levels in evaluating vascular endothelial dysfunction in patients with type 2 diabetes mellitus (T2DM) in the highland area. Methods: Sixty patients with T2DM in high altitude area and 60 healthy people as control group were selected. The levels of serum resistin, TNF-α, NO, vWF and CRP were measured and compared. Results: Serum levels of resistin, TNF-α, vWF and CRP in patients with T2DM were higher than those in normal control group (all P <0.05). The NO level in T2DM patients was lower than that in control group (P <0.01). There was a positive correlation between resistin and TNF-α, vWF and CRP in T2DM patients (r = 0.47, r = 0.32, r = 0.42; all P < 0.05; r = 0.42, P <0.01). Resistin, TNF-α and NO was negatively correlated (r = -0.47, r = -0.34; P <0.01). CONCLUSIONS: Serum levels of resistin and TNF-α are elevated in patients with T2DM in the plateau and are positively or negatively correlated with the indices of vascular endothelial function, suggesting that serum resistin and TNF-α may be related to the occurrence of T2DM vascular complications. A valuable indicator of vascular complications in patients with T2DM.