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为探讨新生儿缺氧缺血性脑病（ＨＩＥ）对儿童神经系统发育的远期影响，对ＨＩＥ存活儿童（４～７岁）４３例（均经临床及头颅ＣＴ证实），进行智商（ＩＱ）和社会生活适应能力（ＳＭ）测定。结果：ＨＩＥ轻度１１例ＩＱ和ＳＭ测评分平均为８５±１２．９０、８．６３±０．９５，中度１９例分别为５６．４７±１１．５０、６．０５±０．６５；重度１３例分别为３０．０７±７．８４、５．３８±０．６０；组间差异均有显著性（Ｐ＜０．０５）。其中３例中度ＨＩＥ患儿接受早期干预、综合治疗３年，ＩＱ和ＳＭ测评分均有不同程度提高。观察表明，神经系统受损程度与ＨＩＥ病情严重程度密切相关；接受早期干预、坚持综合治疗，可不同程度改善患儿预后。
To investigate the long-term effect of neonatal hypoxic-ischemic encephalopathy (HIE) on the development of children’s nervous system, 43 children with HIE (4-7 years old), confirmed by clinical and cranial CT, were enrolled in this study. IQ, And social life ability (SM) determination. Results: The average scores of IQ and SM in 11 mild HIE patients were 85 ± 12.90 and 8.63 ± 0.95, respectively, and those in moderate HIE were 56.47 ± 11.50 and 6.05 ± 0.65, respectively. Severe 13 cases were 30.07 ± 7.84,5.38 ± 0.60; differences between groups were significant (P <0.05). Among them, 3 cases of moderate HIE received early intervention. After 3 years of comprehensive treatment, IQ and SM test scores improved to some extent. Observation shows that the degree of nervous system damage is closely related to the severity of HIE; accept early intervention, adhere to the comprehensive treatment, to varying degrees, improve the prognosis of children.