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随着抗生素、免疫抑制剂等的使用日益增多,条件致病性真菌感染明显增加,其中主要由念珠菌引起。这类感染常用抗真菌抗生素治疗,不但疗效不佳,且副作用大。选用有联合协同或累加作用的两种药物治疗细菌性感染在临床早已广泛应用,但有协同或累加抗念珠菌作用药物的报道尚不多见,为了筛选并研究这类药物,我们从本教研室曾筛选出的一些对念珠菌有抑制作用的药物与已在国内报道的抗念珠菌药物和临床上应用的抗念珠菌药物,进行两两配伍,寻找有联合抗念珠菌作用的药物,为临床应用新的有效药物,提供有益的参考。
With the increasing use of antibiotics, immunosuppressive agents and the like, opportunistic fungal infections have increased significantly, mainly caused by Candida. Commonly used anti-fungal antibiotics such infections, not only poor efficacy, and side effects. The use of a combination of synergistic or additive effects of two drugs in the treatment of bacterial infections has long been widely used in clinical practice, but there are reports of synergistic or additive anti-Candida drugs is rare, in order to screen and study of such drugs, we from the Department Candidates have been screened for the inhibition of Candida drugs have been reported in the domestic anti-Candida drugs and clinical application of anti-Candida drugs for any pair of compatibility, looking for a combination of anti-Candida drugs for clinical Application of new and effective drugs, provide a useful reference.