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以往把苯胺视为膀胱癌的病原物质,Rehn将其称为苯胺癌。但此见解后来被否定,认为苯胺癌的病因并非苯胺本身而是由于苯胺中的不纯物所致。近年来对苯胺的致癌性又引起了人们的注意。1978年美国NCI就报告了苯胺对大鼠有致癌作用。作者用苯胺特级试剂及邻-氨基酚,间-氨基酚和对-氨基酚进行了比较实验。将上述各种化学物质分别经口给予体重300克
In the past, aniline was considered a causative agent of bladder cancer and Rehn called it aniline cancer. However, this opinion was later denied that the cause of aniline cancer is not aniline itself but due to aniline in the impurities. In recent years, the carcinogenicity of aniline has aroused people’s attention. In 1978 the United States NCI reported aniline carcinogenic effect in rats. The authors used aniline class reagent and o-aminophenol, m-aminophenol and p-aminophenol were compared experiments. Each of the above chemical substances were orally administered to a body weight of 300 grams