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目的探讨40岁以下妇女卵巢上皮性癌的临床、病理特点及预后。方法回顾性分析我院1991年1月~2000年12月期间收治的40岁以下妇女卵巢上皮性癌73例患者的临床资料。结果73例患者确诊为卵巢上皮性癌的中位平均年龄为33岁,多以腹痛,腹胀和盆腔包块为主要症状,49例(67·1%)为单侧,肿瘤最大径线平均为15·4cm,所有患者均接受肿瘤减灭术,57例(78·1%)达到理想的肿瘤细胞减灭术,病理分级为G1、G2、G3级者分别为45·2%(33/73)、34·2%(25/73)、20·6%(15/73)。病理类型以浆液性囊腺癌和粘液性囊腺癌最常见,占78·1%(57/73)。41例(56·2%)临床分期为Ⅰ期和Ⅱ期。所有患者均接受了化疗,5年生存率53·4%。本病预后与临床分期、细胞学分级、手术彻底性有良好的相关性。结论40岁以下妇女患者卵巢上皮性癌较少见,肿瘤体积较大,单侧多见,早期,高分化多见,经手术和化疗,预后相对较好。
Objective To investigate the clinical, pathological features and prognosis of epithelial ovarian cancer in women under 40 years of age. Methods The clinical data of 73 patients with ovarian epithelial carcinoma under 40 years of age admitted from January 1991 to December 2000 in our hospital were retrospectively analyzed. Results The median age of 73 cases diagnosed as epithelial ovarian cancer was 33 years old. The main symptoms were abdominal pain, abdominal distension and pelvic mass, 49 cases (67.1%) were unilateral, the largest average diameter of tumor was 15.4 cm. All the patients underwent tumor ablation. 57 patients (78.1%) achieved the ideal cytoreductive surgery. The pathological grade was G1, G2, and G3, 45.2% (33/73) ), 34.2% (25/73) and 20.6% (15/73). Pathological types of serous cystadenocarcinoma and mucinous cystadenocarcinoma are the most common, accounting for 78.1% (57/73). 41 cases (56.2%) clinical stage Ⅰ and Ⅱ. All patients received chemotherapy and the 5-year survival rate was 53.4%. The prognosis of the disease and clinical stage, cytological grade, surgical thoroughness has a good correlation. Conclusions Ovarian epithelial carcinoma is rare in women under 40 years of age. The tumor size is large, unilateral more common, early, more common differentiation, surgery and chemotherapy, the prognosis is relatively good.