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目的:探讨早期宫颈小细胞神经内分泌癌(SCNEC)的临床特点、治疗及预后。方法:回顾性分析20例SC-NEC患者的临床、病理及随访资料。结果:20例患者的中位年龄为38岁(32～52岁),均行子宫颈癌根治术,术后进行同步放化疗及辅助化疗;术后脉管累及13例,深层间质浸润9例,4例有盆腔淋巴结转移,6例治疗后发生远处转移;中位生存期22个月,总的2年和5年生存率分别为45.0%和25.0%。结论:早期SCNEC具有高度侵袭的生物学行为,预后差,易复发和转移,辅助放疗、化疗可能会提高患者的生存率。
Objective: To investigate the clinical features, treatment and prognosis of early cervical small cell neuroendocrine carcinoma (SCNEC). Methods: The clinical, pathological and follow-up data of 20 patients with SC-NEC were retrospectively analyzed. Results: The median age of the 20 patients was 38 years old (32 to 52 years old). The patients underwent radical mastectomy with concurrent chemoradiation and adjuvant chemotherapy. Thirteen patients had vascular involvement and deep interstitial infiltration 9 Cases, 4 cases of pelvic lymph node metastasis, 6 cases of distant metastasis after treatment; median survival of 22 months, the total 2-year and 5-year survival rates were 45.0% and 25.0%. Conclusion: Early SCNEC has a highly invasive biological behavior with poor prognosis, easy recurrence and metastasis, adjuvant radiotherapy and chemotherapy may improve the survival rate of patients.