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血管紧张素Ⅱ(ANG Ⅱ)是肾素-血管紧张素系统(RAS)中重要的介质,它作用于特异性受体,导致血管收缩和醛固酮的释放。Losartan是一种口服有效、代谢稳定、具有选择性的ANGⅡ受体阻滞剂。它具有血管扩张效应,有防止容量超负荷引起心肌肥厚及左室扩大的作用,增加冠脉流量,与卡托普利、依那普利等ACEⅠ相比,Losartan的作用时间长、不良反应少、耐受性好,临床上是一种新的、高效能的治疗高血压和充血性心表的药物。
Angiotensin II (ANG II) is an important mediator of the renin-angiotensin system (RAS) and acts on specific receptors, leading to vasoconstriction and aldosterone release. Losartan is an orally available, metabolically stable and selective ANG II receptor blocker. It has a vasodilator effect, to prevent excessive volume overload caused by cardiac hypertrophy and left ventricular enlargement, and increase coronary flow, and captopril, enalapril and other ACE Ⅰ compared Losartan role for a long time, fewer adverse reactions , Well tolerated, clinically a new, high-potency drug for the treatment of hypertension and congestive heart failure.