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本文选择18～55岁、停用各种治疗的缓解期鼻炎患者,在变应原、干冷空气等刺激因素诱发其症状急性发作时,采用鼻灌洗法收集鼻分泌物,然后通过荧光光谱分析,放射免疫及高压液相色谱(HPLC)等方法分析,测定灌洗液中组胺、激肽、TAME酯酶(N-α-tosyl-L-arginine methyl eaterase,甲苯磺酰精氨酸酯酶)、PGD_2及白细胞三烯等炎性介质。体内、外研究表明,组胺及其他肥大细胞介质的释放与变应原鼻激发试验的急性反应相关。并发现在初次鼻腔灌洗液中即含高水平的组胺,且与特应状态无关。用变应原作鼻粘膜激发试验时,变应性患者除出现明显的过敏反应外,60％伴有灌洗液组胺水平增
In this paper, rhinitis patients with erectile dysfunction aged 18 to 55 years old who were stopped using various treatments were collected nasal lavage to collect their nasal secretions during the acute onset of symptoms induced by allergens, cold and dry air, and then analyzed by fluorescence spectroscopy , Radioimmunoassay and high pressure liquid chromatography (HPLC) were used to analyze the contents of histamine, kinin, TAME esterase (tosyl-arginine esterase ), PGD_2 and leukotrienes and other inflammatory mediators. In vitro and in vivo studies have shown that the release of histamine and other mast cell mediators is associated with an acute response to the allergen nasal challenge test. It was found to contain high levels of histamine in primary nasal lavage fluid, independent of the state of the atopy. Allergen used for nasal mucosal challenge test, allergic patients in addition to significant allergic reactions, 60% with lavage fluid histamine increased