论文部分内容阅读
革兰氏阴性菌侵入组织可引起炎症反应,系由细胞壁中脂多糖(LPS)所致。已证明,LPS的类脂A能刺激各种细胞,从而导致炎症,其中某些反应是有毒性的,如降低血压、血液凝固紊乱、致死作用,而另一些则是有益的,如增强抗体合成及吞噬细胞移动。虽有人用体液或细胞方法使LPS脱毒,但尚未提及特异性酶的作用机理。本文报道,人类中性粒细胞酶使LPS部分脱酰基后,极大地降低其毒性,但仍能保留免疫刺激能力。
Gram-negative bacteria invade the tissue can cause inflammation, caused by the lipopolysaccharide (LPS) in the cell wall. It has been demonstrated that lipopolysaccharide L of LPS stimulates a variety of cells leading to inflammation, some of which are toxic, such as lowering blood pressure, blood coagulation disorders, and lethal effects, while others are beneficial, such as enhancing antibody synthesis And phagocytic cells move. Although some people use humoral or cellular methods to detoxify LPS, no specific mechanism of action of the enzyme has been mentioned yet. This article reports that human neutrophil enzymes, which partially deacylate LPS, greatly reduce their toxicity but still retain the ability to immunostimulate.