Thermal stability and hydration behavior of ritonavir sulfate： A vibrational spectroscopic approach

• 作 者: Kaweri Gambhir Parul Singh Dee
• 机 构: QuantumOpticsandPhotonPhysics
• 出 处: 药物分析学报：英文版
• 发表日期: 2015年6期
• 关键词: 振动光谱 热稳定性 硫酸盐 水化 傅里叶变换红外光谱 行为 蛋白酶抑制剂 原子力显微镜 Ritonavir sulfateDiffuse reflectance
• 基金项目: AcknowledgmentsThe authors are thankful to the Director, CSIR-National Physical Laboratory, New Delhi, India, for granting the permission to publish this work.

Ritonavir sulfate is a protease inhibitor widely used in the treatment of acquired immunodeficiency syndrome. In order to elucidate the inherent stability and sensitivity characteristics of ritonavir sulfate, it was investigated under forced thermal and h