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先锋霉素是一族广谱的半合成头孢菌素,其共同母核为7-氨基头孢霉烷酸。1945年国外发现一株头孢菌(Cephalospor-ium acremonium)的提取物具有治疗伤寒和布氏杆菌病的作用后,于1955年,1962年进一步分离,发现其中含有三种完全不同的抗菌素,即头孢菌素N(青霉素N)、头孢菌素P(甾体结构,与褐霉素相似)和头孢菌素C。头孢菌素C,由于它具有抗耐药金葡菌的作用和毒性非常低的特点而引起人们的注意,但其抑菌浓度较高,抗菌活力不够满意。此时青霉素结构改造工作正在进行,因此对头孢
Vanguard ADM is a family of broad-spectrum semisynthetic cephalosporins with a common core of 7-aminocephalosporanic acid. 1945 abroad found a Cephalosporum (Cephalospor-ium acremonium) extract has the treatment of typhoid and brucellosis after the further separation in 1955 and 1962 and found that it contains three completely different antibiotics, cephalosporins N (penicillin N), cephalosporin P (steroid structure similar to Fusidin) and cephalosporin C. Cephalosporin C has drawn people’s attention due to its anti-drug-resistant role of Staphylococcus aureus and its very low toxicity. However, its antibacterial concentration is high and its antibacterial activity is not satisfactory. At this point penicillin structural transformation work is ongoing, so cephalosporin