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微核糖核酸(microRNAs,miRNAs)是广泛存在于真核生物中的一类短小的、不编码蛋白质的RNA家族,由18-25个核苷酸组成的单链RNA。研究表明microRNAs对肿瘤的发生发展具有重要的调节作用。肿瘤血管生成是实体瘤侵袭转移的关键步骤,抗肿瘤血管生成的治疗已成为当前研究的焦点,已有研究表明,microRNAs参与肿瘤血管生成的调节作用,通过对肿瘤血管生成相关因子的调控,影响肿瘤生成。
MicroRNAs (miRNAs) are a family of short, non-protein-coding RNA family of 18-25 nucleotide single-stranded RNAs widely found in eukaryotes. Studies have shown that microRNAs have an important regulatory role in tumorigenesis. Tumor angiogenesis is a key step in the invasion and metastasis of solid tumors. The treatment of anti-angiogenesis has become the focus of current research. It has been shown that microRNAs are involved in the regulation of tumor angiogenesis through the regulation of tumor angiogenesis-related factors Tumor formation.