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精神分裂症是一种严重的精神疾病,但确切的机制至今尚未研究透彻. 近来,研究者们发现D1、D2 受体的过度活化、多巴胺和环腺苷酸调节的磷蛋白的调节机制、受体磷酸化磷酸酶 β/ζ的编码基因PTPRZ1(蛋白酪氨酸磷酸酶,受体类型,Z多肽1)与精神分裂症密切相关;γ氨基丁酸α受亚单位α5 受体进行变构调节,能逆转多巴胺功能异常亢进,进而缓解精神分裂症的阳性症状.“,”Schizophrenia is a serious mental disease.However, its exact pathogenesis has not yet been well studied.Recently, researchers have found that the excessive activation of D1 ,D 2 receptors, regulation mechanism of DARPP-32 ,and encoding genes PTPRZ1 of RPTPβ/ζare factors that closely related to schizo-phrenia;allosteric regulation of α5 GABAA receptor can reverse dopamine dysfunction disease,thereby allevi-ate the positive symptoms of schizophrenia.