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本文报道1985～1993年间静脉纤溶治疗16例基底动脉急性闭塞病人。男性11例,女性5例,平均年龄62岁(31～78岁)。由临床诊断和血管造影(13例)、经颅多普勒超声检查(TCD)(8例)证实基底动脉闭塞。自发病至溶栓治疗间隔6小时内13例,7小时1例,时间不明1例。每例给组织型纤溶酶原激活剂100mg,用肝素(800～1000Iu/h)维持活化部分促凝血酶原激酶时间为对照的1.5～2倍,还按中风的常规治疗给5天的羟乙基淀粉(500ml/d)、己酮可可碱(200mg/d)。溶栓治疗后血管造影2例、TCD14例,若血管造影或TCD示基底动脉开放,则表明再通成功,否则为未通。 结果:再通10例,幸存5例,除1例74岁,幸存
This article reports from 1985 to 1993 intravenous fibrinolytic treatment of 16 patients with acute basilar artery occlusion. There were 11 males and 5 females, with an average age of 62 years (31-78 years). Basilar artery occlusion was confirmed by clinical diagnosis and angiography (13 cases) and transcranial Doppler echocardiography (TCD) (8 cases). From the onset of thrombolytic therapy to 6 hours interval within 13 cases, 7 hours in 1 case, time unknown in 1 case. Each case of tissue-type plasminogen activator 100mg, with heparin (800 ~ 1000Iu / h) to maintain activated partial thromboplastin time 1.5 to 2 times the control, but also by conventional stroke treatment to 5 days of hydroxyl Ethyl starch (500 ml / d), pentoxifylline (200 mg / d). Thrombolytic therapy after angiography in 2 cases, TCD 14 cases, if angiography or TCD showed basilar artery open, then the success of re-pass, otherwise not yet. Results: Recanalization in 10 cases, survived in 5 cases, except one case of 74 years old, survived