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目的探讨肿瘤坏死因子α诱导蛋白3(TNFAIP3)基因rs2230926位点多态性与重症肌无力(MG)的关系。方法采用聚合酶链反应-限制性内切酶(PCR-RFLP)技术分析125例MG患者与143名健康对照者rs2230926位点基因型。结果在中国北方地区汉族人群中TNFAIP3 rs2230926位点仅有T/T和T/G两个基因型。发病年龄≥40岁的MG患者中T/G基因型及G等位基因出现频率较发病年龄<40岁的MG患者高(P<0.05)。结论 TNFAIP3 rs2230926位点与中国北方地区晚发型MG患者发病相关。
Objective To investigate the relationship between rs2230926 polymorphism of tumor necrosis factor α inducible protein 3 (TNFAIP3) gene and myasthenia gravis (MG). Methods The genotypes of rs2230926 in 125 patients with MG and 143 healthy controls were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results There were only T / T and T / G genotypes in TNFAIP3 rs2230926 locus in northern Chinese Han population. The prevalence of T / G genotype and G allele in patients with MG≥40 was higher than that in patients with MG <40 years of age (P <0.05). Conclusion TNFAIP3 rs2230926 locus is associated with the onset of late-onset MG in northern China.