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近5年来对于皮肤组胺受体有了更多的了解。组胺对皮肤的生理及病理过程有着广泛的作用。它促使免疫复合物容易穿透到内皮下方,因而加重血管的损伤;它可能调节皮肤迟发型变态反应和调节 T 细胞功能;它还可能控制表皮的生长。本文在下述诸方面作一简要复习。血管受体继1972年 Wyllie 等的初步观察及 Black等观察到组胺衍生物2-甲基组胺和4-甲基组胺分别具有显著的 H_1和 H_2受体激动剂作用,1978年 Robertson 等证明人类皮肤血管有两种组胺受体,2-甲基组胺和4-甲基组胺都能引起与剂量相应的红斑,但轴索反射
In the past 5 years for skin histamine receptors have more understanding. Histamine has a broad effect on the physiology and pathology of the skin. It promotes the immune complex to penetrate easily beneath the endothelium, thus exacerbating vascular damage; it may regulate delayed skin type allergy and regulate T cell function; it may also control the growth of the epidermis. This article makes a brief review of the following aspects. Vascular Receptors Following the preliminary observations by Wyllie et al in 1972 and Black et al., The histamine derivatives 2-methylhistamine and 4-methylhistamine have significant H 1 and H 2 receptor agonist effects, respectively. In 1978 Robertson et al It has been demonstrated that there are two histamine receptors on human skin blood vessels. Both 2-methylhistamine and 4-methylhistamine can cause erythema associated with dose, but axonal reflex