论文部分内容阅读
目的了解老年感染性发热患者的常见发热原因及其T淋巴细胞亚群、免疫球蛋白的变化情况,分析老年感染性发热与其免疫功能的相关性。方法对2006-2009年我院感染科收治的100例感染性发热的老年住院患者的病因及病原微生物进行分析,应用流式细胞术检测患者外周血T淋巴细胞亚群,采用免疫比浊法检测免疫球蛋白IgA、IgG、IgM,并与40名健康体检老年人及40名健康体检年轻人对照。结果老年感染性发热最常见的原因为肺部感染、尿路感染、胆道感染等,以细菌性感染最多见。健康老年人较健康年轻人CD3+、CD4+明显下降。感染性发热老年组CD3+、CD4+、CD4+/CD8+较健康年轻组明显下降,而IgM、IgG高于健康年轻组;IgA、IgM、IgG、CD8+水平显著高于健康老年组。结论老年感染性发热的病因以细菌性感染为主,老年感染性发热与其免疫功能紊乱相关,表现为T细胞免疫功能低下及调节网络平衡失调,体液免疫紊乱,故感染性发热老年患者在抗感染的同时应注意调节患者的免疫功能。
Objective To understand the causes of common fever and changes of T lymphocyte subsets and immunoglobulins in elderly patients with infectious fever and to analyze the correlation between senile infectious fever and immune function. Methods Etiology and pathogenic microorganisms in 100 hospitalized patients with infectious fever in our hospital from 2006 to 2009 were analyzed. T lymphocyte subsets in peripheral blood were detected by flow cytometry. Immunoturbidimetry Immunoglobulin IgA, IgG, IgM, and with 40 healthy elderly and 40 healthy young people control. Results The most common causes of infective fever in the elderly were pulmonary infection, urinary tract infection, biliary tract infection, and bacterial infection. Healthy elderly than healthy young people CD3 +, CD4 + decreased significantly. The levels of CD3 +, CD4 +, CD4 + / CD8 + were significantly lower in elderly patients with infectious febrile disease than those in healthy young patients, while the levels of IgM and IgG were higher in healthy older patients than in healthy young patients. The levels of IgA, IgM, IgG and CD8 + were significantly higher in elderly patients with infectious fevers than in healthy seniors. Conclusions The main cause of septic fever in elderly patients is bacterial infection. Senile infectious fever is related to immune dysfunction. It manifests as T cell immune dysfunction and disorders of balance of network and humoral immune disorders. Therefore, At the same time should pay attention to regulate the patient’s immune function.