Porphyromonas gingivalis Resistance to Polymyxin B Is Determined by the Lipid A 4＇-Phosphatase, PGN_

• 作 者: Stephen R. Coats Thao T. To Su
• 机 构: DepartmentofPeriodontics
• 出 处: 国际口腔科学杂志：英文版
• 发表日期: 2009年3期
• 关键词: 口腔 病原体 抗菌剂 磷酸酶 脂多糖 P. gingivalis antimicrobial peptide lipid A phosphatase po
• 基金项目: supported by NIH grant (DE 12768) to R. P. D.

Aim To elucidate the genetic basis for the pronounced resistance that the oral pathogen, Porphyromonas gingivalis (P. gingivalis), exhibits towards the cationic antimicrobial peptide, polymyxin B. Methodology A genetic screen of P. gingivalis clones gener