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目的分析医院新生儿细菌性肺炎的常见致病菌及其耐药情况,为临床合理选用抗菌药物,快速有效的控制新生儿细菌性肺炎提供实验依据。方法从医院2013年7月至2015年6月新生儿科送检的痰标本中分离致病菌,采用法国生物梅里埃分司的API系统进行细菌鉴定,K-B法和E-test法进行药物敏感性试验。用Whonet5.6对所有数据进行统计计算。结果从送检的痰标本中共分离出380株细菌,其中大肠埃希菌分离率最高,达35.8%,其次是金黄色葡萄球菌和肺炎克雷伯菌,分别为24.2%和22.6%。其对新生儿常用抗菌药物均产生了一定程度的耐药性。结论大肠埃希菌、金黄色葡萄球菌和肺炎克雷伯菌是引起新生儿细菌性肺炎的常见致病菌,其对常用抗菌药物均产生了一定的耐药性,应当加强检测与控制,并根据药敏试验结果和新生儿抗菌药物的临床使用规范合理选用抗菌药物。
Objective To analyze the common pathogenic bacteria and drug resistance of neonatal bacterial pneumonia in hospitals and to provide experimental basis for the rational use of antibacterial drugs clinically and the rapid and effective control of neonatal bacterial pneumonia. Methods Pathogenic bacteria were isolated from the sputum from the hospital from July 2013 to June 2015, and the bacteria were identified by the API system of French Merrellis Division. The KB and E-test methods were used to determine the drug sensitivity test. With Whonet5.6 statistical calculation of all data. Results A total of 380 bacteria were isolated from sputum samples, of which 35.8% were Escherichia coli, followed by Staphylococcus aureus and Klebsiella pneumoniae, accounting for 24.2% and 22.6% respectively. The newborn common antibacterial drugs have produced a certain degree of resistance. Conclusion Escherichia coli, Staphylococcus aureus and Klebsiella pneumoniae are common pathogenic bacteria that cause bacterial pneumonia in newborns. They have some resistance to commonly used antimicrobial drugs, and should be strengthened to detect and control According to drug susceptibility test results and clinical use of neonatal antimicrobial drugs rational use of antimicrobial agents.