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患者男,29岁,因车祸行颅内血肿清除术+去骨瓣减压术,手术顺利,恢复良好,无药物过敏史。于2011年入科,后行颅骨修补术,术后患者出现持续发热,体温波动在38～39℃,行腰椎穿刺术可见血性脑脊液引出,留置腰大池引流管,脑脊液常规:白细胞:2.0×109/L,考虑颅内感染。使用抗生素注射用万古霉素0.5g加入0.9%氯化钠注射液100mL,2次/d,9～21,静脉滴注,10min患者出现颈部、颜面部发烫,潮红,无疼痛,不痒,考虑万古霉素过敏,予以停药,30min后症状缓解。
Male, 29 years old, because of a car accident line of intracranial hematoma removal + decompressive craniectomy, the operation was smooth, well recovered, no history of drug allergy. In 2011, he received cranioplasty after operation, and postoperative fever continued to occur. The body temperature fluctuated between 38 and 39 ° C. Lumbar puncture showed that bloody cerebrospinal fluid (CSF) was withdrawn and lumbar drainage was reserved. Cerebrospinal fluid routine: WBC: 2.0 × 109 / L, consider intracranial infection. The use of antibiotics 0.5g vancomycin injection 0.9% sodium chloride injection 100mL, 2 times / d, 9 ~ 21, intravenous infusion, 10min patients with neck, facial hot, flushing, no pain, itching , Consider vancomycin allergy, to be discontinued, 30min after the symptoms ease.