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ZNC(C)PR是大鼠脑中具有促进学习记忆作用的神经肽,本文按前文2D-NMR测 定结构和活性比较的结果以及分子动力学的关 类似物加以验证。结果与预则相符,即一定系式计算了45个ZNC(C)PR类似物的能量和紧密度的分子结构是表现活性所必需的。可能的结构趋向,从理论上探讨了各残基对稳定结构的贡献,并据此设计和合成了5个新的
ZNC (C) PR is a neuropeptide that plays a role in learning and memory in the rat brain. This article verifies the structure-activity comparison and the molecular dynamics-related analogues of 2D-NMR. The result is in line with the prediction that the molecular structure of 45 ZNC (C) PR analogues calculated for energy and compactness is necessary to characterize activity. Possible structural tendency, and theoretically discussed the contribution of each residue to the stable structure. Based on this, five new