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目的通过比较消化性溃疡、胃炎患者及正常人胃粘膜组织一氧化氮合酶（ＮＯＳ）的活性，探讨ＮＯＳ和一氧化氮（ＮＯ）在消化性溃疡发病和转归过程中所起的作用，以及年龄因素对胃粘膜组织ＮＯＳ活性的影响。方法共收集了７８份胃粘膜标本，其中胃溃疡病人２３例，十二指肠球部溃疡２７例，浅表性胃炎１７例，正常志愿者１１例；采用高铁血红蛋白比色法检测ＮＯＳ的活性。结果胃溃疡患者ＮＯＳ活性显著高于正常对照组（Ｐ＜０．０２）；十二指肠球部溃疡患者及浅表性胃炎患者ＮＯＳ活性与正常对照组相比均无显著性差异；不同年龄组胃溃疡、十二指肠球部溃疡、胃炎患者胃粘膜组织中ＮＯＳ活性无显著性差异。结论胃溃疡患者ＮＯＳ活性升高，可能是机体为修复胃粘膜而引发的一种代偿反应，将有利于溃疡的愈合；年龄不是影响胃粘膜组织ＮＯＳ活性的主要因素
Objective To investigate the role of NOS and nitric oxide (NO) in the pathogenesis and prognosis of peptic ulcer by comparing the activity of nitric oxide synthase (NOS) in gastric mucosa of patients with peptic ulcer, gastritis and normal gastric mucosa, And age factors on gastric mucosal NOS activity. Methods A total of 78 specimens of gastric mucosa were collected, including 23 gastric ulcer patients, 27 ulcer of duodenal ulcer, 17 superficial gastritis and 11 normal volunteers. The activity of NOS was detected by methemoglobinimetric assay . Results The NOS activity of gastric ulcer patients was significantly higher than that of the normal control group (P <0.02). The activity of NOS in patients with duodenal ulcer and superficial gastritis had no significant difference compared with the normal control group. Group gastric ulcer, duodenal ulcer, gastritis in gastric mucosal tissue NOS activity was no significant difference. Conclusion The increased activity of NOS in patients with gastric ulcer may be a compensatory reaction caused by the body to repair the gastric mucosa, which will be beneficial to the healing of ulcer. Age is not the main factor affecting the activity of NOS in gastric mucosa