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目的观察早期肠内营养联合微生态制剂在改善危重病患者胃肠功能的临床疗效。方法 ICU危重病患者276例随机均分成两组:试验组患者行早期肠内营养联合双歧杆菌三联活菌鼻饲治疗;对照组患者单纯行早期肠内营养治疗。比较两组治疗前后相关实验室检测指标,分析胃肠道并发症发生情况。结果两组患者治疗10d后,白蛋白(Alb)升高,Hb、C反应蛋白(CRP)、乳酸脱氢酶(LDH)和WBC计数降低(P<0.05),试验组的改善程度优于对照组(P<0.05)。试验组患者腹胀、腹泻、呕吐、便秘和上消化道出血发生率也低于对照组(P<0.05)。结论危重病患者早期肠内营养联合微生态制剂治疗能有效保护胃肠道功能,维护机体内环境稳定,减少并发症。
Objective To observe the clinical efficacy of early enteral nutrition combined with probiotics in improving gastrointestinal function in critically ill patients. Methods A total of 276 ICU critically ill patients were randomly divided into two groups: the experimental group received early enteral nutrition combined with Bifidobacterium triple viable nasal feeding; the control group received simple enteral nutrition alone. Before and after treatment, the relevant laboratory test indicators were compared to analyze the incidence of gastrointestinal complications. Results After treatment for 10 days, the albumin (Alb), the levels of Hb, C-reactive protein (CRP), lactate dehydrogenase (LDH) and WBC in the two groups were decreased (P < Group (P <0.05). The incidences of bloating, diarrhea, vomiting, constipation and upper gastrointestinal bleeding in the test group were also lower than those in the control group (P <0.05). Conclusion The treatment of early enteral nutrition combined with probiotics in critically ill patients can effectively protect the gastrointestinal function, maintain the stable environment in the body and reduce the complications.