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由纯净一氧化氮或由硝基甘油而来的一氧化氮均降低人血小板一氧化氛合成酶活性，但不影响一氧化氛合成酶蛋白在人血小板会成。一氧化氮合成酶活性的下调节作用，可能是硝酸盐耐受性所致。硝基甘油和保证一氧化氮对人血小板一氧化氮合成酶活性的下调节作用
Nitric oxide from pure nitric oxide or from nitroglycerin both reduce the activity of human platelet monooxygenase synthase, but do not affect the synthesis of an oxidative synthetase protein in human platelets. Nitric oxide synthase activity down regulation, may be due to nitrate tolerance. Nitroglycerin and nitric oxide assure the down-regulation of human platelet nitric oxide synthase