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曾有报导锰可引起“假变态反应”,并可使机体过敏。动物在锰化合物中毒时嗜酸性细胞增多。由于组胺酶活性和固定组织胺降低而使血中组织胺增高;前者的变化在同时受异体蛋白致敏时表现得十分明显。锰能引起蛋白质变性和改变生物胶体的吸附特点。应注意锰在门捷列夫周期系中与已知化学致敏原(铬、镍、钴)靠近。作者指出长期受非中毒剂量锰作用的雄性动物的后代对锰的毒性作用敏感性提
It has been reported that manganese can cause “pseudo-allergy” and can make the body allergic. Animals eosinophilia when manganese compounds are poisoned. Histamine increased in the blood due to histamine enzyme activity and decreased fixed histamine; changes in the former were most pronounced when sensitized by allogeneic proteins. Manganese can cause protein denaturation and change the adsorption characteristics of biological colloids. It should be noted that manganese approaches the known chemical allergens (chromium, nickel, cobalt) in the Mendeleev cycle. The authors point out that the offspring of male animals, long-term exposed to non-toxic doses of manganese, are sensitive to the toxic effects of manganese