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AIM:To evaluate gastrointestinal(GI) symptoms and breath hydrogen responses to oral fructose-sorbitol(F-S) and glucose challenges in eating disorder(ED) patients.METHODS:GI symptoms and hydrogen breath concentration were monitored in 26 female ED inpatients for 3 h,following ingestion of 50 g glucose on one day,and 25 g fructose/5 g sorbitol on the next day,after an overnight fast on each occasion.Responses to F-S were compared to those of 20 asymptomatic healthy females.RESULTS:F-S provoked GI symptoms in 15 ED patients and one healthy control(P < 0.05 ED vs control) .Only one ED patient displayed symptom provocation to glucose(P < 0.01 vs F-S response) .A greater symptom response was observed in ED patients with a body mass index(BMI) ≤ 17.5 kg/m 2 compared to those with a BMI > 17.5 kg/m 2(P < 0.01) .There were no differences in psychological scores,prevalence of functional GI disorders or breath hydrogen responses between patients with and without an F-S response.CONCLUSION:F-S,but not glucose,provokes GI symptoms in ED patients,predominantly those with low BMI.These findings are important in the dietary management of ED patients.
AIM: To evaluate gastrointestinal (GI) symptoms and breath hydrogen responses to oral fructose-sorbitol (FS) and glucose challenges in eating disorder (ED) patients. METHODS: GI symptoms and hydrogen breath concentration monitored in 26 female ED inpatients for 3 h , the following ingestion of 50 g glucose on one day, and 25 g fructose / 5 g sorbitol on the next day after an overnight fast on each occasion. Responses to FS were compared to those of 20 asymptomatic healthy females .RESULTS: FS provoked GI symptoms in 15 ED patients and one healthy control (P <0.05 ED vs. control) .Only one ED patient displayed symptom provocation to glucose (P <0.01 vs FS response). A greater symptom response was observed in ED patients with a body mass index (BMI) ≤ 17.5 kg / m 2 compared to those with a BMI> 17.5 kg / m 2 (P <0.01) .There were no differences in psychological scores, prevalence of functional GI disorders or breath hydrogen responses between patients with and without an FS response.CONCLUSION: FS, b ut not glucose, provokes GI symptoms in ED patients, predominantly those with low BMI. These findings are important in the dietary management of ED patients.