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伊他康唑(itraconazole)是一种口服有效的三氮唑族广谱抗真菌剂。对常见真菌感染,如阴道念珠菌病、花斑癣、皮肤癣菌病均有明显疗效,对全身性真菌病亦见良至优的效果。伊他康唑对组织有高度的亲和性,其组织浓度数倍于其相应的血浆浓度峰值。本文观察了正常志愿者口服伊他康唑100～200mg/d 后在皮肤内的药动学。从用药7天起,胡须部及背部组织的浓度即持续地高于相应的血浆浓度。手掌角层的浓度比相应的血浆浓度低,但在停药后仍持续3周。胡须部位角质在治疗结束后4周
Itraconazole is an orally available triazole-based broad-spectrum antifungal agent. Of common fungal infections, such as vaginal candidiasis, pityriasis versicolor, dermatophytosis have significant effect on systemic fungal disease also see good to excellent results. Itraconazole has a high degree of tissue affinity with several times its tissue concentration at its corresponding peak plasma concentration. This article observed the normal volunteers oral itraconazole after 100 ~ 200mg / d in the skin pharmacokinetics. From the 7th day after treatment, the concentrations of beard and dorsal tissues were consistently higher than the corresponding plasma concentrations. The concentration in the cortex of the hand was lower than the corresponding plasma concentration but continued for 3 weeks after discontinuation. Beard parts keratin 4 weeks after the end of treatment