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脂氧素(LX)是花生四烯酸的一类脂氧化酶产物,在多个器官的缺血/再灌注损伤中起着必不可少的作用。LX对多种炎性细胞的功能和多种炎症相关基因的表达有广泛的调节作用,能抑制中性粒细胞活化、聚集,抑制促炎因子的表达,促进炎性反应的及时消退,抑制缺血性损伤向炎症性损伤的转变,减轻脑、心脏、肾脏、胃、肠、肺等器官的缺血/再灌注损伤,LX类似物及LX受体激动剂等也可起到降低器官缺血/再灌注损伤的作用。
Lipoxygenase (LX) is a lipoxygenase product of arachidonic acid and plays an essential role in ischemia / reperfusion injury in multiple organs. LX can regulate the function of many kinds of inflammatory cells and the expression of many inflammatory related genes, inhibit the activation and aggregation of neutrophils, inhibit the expression of proinflammatory cytokines, promote the timely resolution and suppression of inflammatory reaction Change from bloody injury to inflammatory injury and alleviation of ischemia / reperfusion injury in brain, heart, kidney, stomach, intestine, lung and other organs, LX analogues and LX receptor agonists can also reduce organ ischemia / Reperfusion injury.