论文部分内容阅读
目的探讨锝[99Tc]亚甲基二磷酸钠注射液(云克)联合甲氨蝶呤治疗类风湿关节炎的临床疗效。方法选择2013年1月—2015年1月南平市人民医院收治的类风湿关节炎患者50例。根据治疗方式不同分为观察组与对照组,各25例。对照组予以甲氨蝶呤治疗,观察组在对照组基础上加用云克治疗,观察两组患者临床疗效、晨僵时间、关节压痛数、关节肿胀数、红细胞沉降率(ESR)、C反应蛋白(CRP)、类风湿因子(RF)、不良反应发生情况。结果观察组总用效率高于对照组,差异有统计学意义(P<0.05)。两组患者治疗前晨僵时间、关节压痛数、关节肿胀数、ESR、CRP、RF比较,差异无统计学意义(P>0.05);治疗后观察组晨僵时间短于对照组,关节压痛数、关节肿胀数少于对照组,ESR、CRP、RF低于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论云克联合甲氨蝶呤治疗类风湿关节炎的临床疗效显著,可改善患者的临床症状及相关的实验室指标,提高患者预后及生活质量。
Objective To investigate the clinical efficacy of technetium [99Tc] sodium methyldiphosphate injection (Yunke) combined with methotrexate in the treatment of rheumatoid arthritis. Methods From January 2013 to January 2015, 50 patients with rheumatoid arthritis were admitted to Nanping Municipal People’s Hospital. According to different treatment groups were divided into observation group and control group, 25 cases each. The control group was treated with methotrexate. The observation group was treated with Yunke on the basis of the control group. Clinical curative effect, morning stiffness time, joint tenderness, swollen joint count, erythrocyte sedimentation rate (ESR), C reaction Protein (CRP), rheumatoid factor (RF), the occurrence of adverse reactions. Results The total efficiency of the observation group was higher than that of the control group, the difference was statistically significant (P <0.05). There was no significant difference in morning stiffness time, joint tenderness, swollen joint count, ESR, CRP and RF between the two groups before treatment (P> 0.05); the morning stiffness time in the observation group was shorter than that in the control group after treatment , The number of joint swelling was less than that of the control group, but the difference was statistically significant (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Yunke combined methotrexate treatment of rheumatoid arthritis clinical significant effect, can improve the patient’s clinical symptoms and related laboratory indicators, improve patient prognosis and quality of life.