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近来动物研究及临床回顾性资料提示环孢素(CyA)对葡萄糖代谢有不良影响,可致糖尿病。动物体内和体外研究表明,CyA 能减少胰腺胰岛素含量,引起β细胞形态学改变,结果发生葡萄糖不耐受、高血糖症和低胰岛素血症。已证明肾移植后高血糖症发生率在 CyA 治疗的病人有所增高,但其他报告未发现 CyA 对人的胰腺有毒
Recent animal studies and clinical retrospective data suggest that cyclosporine (CyA) has an adverse effect on glucose metabolism, can cause diabetes. In vivo and in vitro studies in animals have shown that CyA decreases pancreatic insulin levels and causes morphological changes in beta cells resulting in glucose intolerance, hyperglycemia and hypoinsulinemia. The incidence of hyperglycaemia after kidney transplantation has been shown to be elevated in CyA-treated patients, but other reports found no toxic effects of CyA on human pancreas