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四环素曾长期广泛地应用于临床。Shwachman(1956)首次报道四环素对牙齿的染色以来,国内外对四环素在牙齿的沉着机理,影响牙齿发育钙化的时期,以及与龋病发生的关系等方面进行了大量的研究和流行病学的调查。目前在我国虽已明文规定不对儿
Tetracycline has long been widely used in clinical. Shwachman (1956) first reported tetracycline on the teeth since the tetracycline in the teeth at home and abroad in the mechanism of calm, affecting the period of tooth development and calcification, and the relationship between caries and other aspects of a large number of studies and epidemiological investigations . Although it is not clearly stated in our country right now