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利尿剂通过抑制肾小管特定部位钠或氯的重吸收,遏制心力衰竭(心衰)时的水钠潴留,纠正体内液体潴留的状态,从而纠治肺淤血,并通过降低心脏前负荷而改善心功能。因此,利尿剂一直被认为是心衰治疗的基石。所有利尿剂均能增加尿量和钠排泄,但其药理学作用不同。襻利尿剂增加尿钠排泄可达钠滤过负荷的20%-
Diuretics can correct the state of fluid retention in the body by inhibiting reabsorption of sodium or chlorine in specific areas of the renal tubules, arresting sodium and water retention during heart failure (heart failure), and correcting the congestion in the body, thereby improving heart congestion and reducing heart preload Features. Therefore, diuretics have long been considered the cornerstone of heart failure treatment. All diuretics can increase urine output and sodium excretion, but their pharmacological effects are different.襻 increased diuretic sodium excretion up to 20% of sodium filtration overload -