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支气管哮喘是由嗜酸性粒细胞、肥大细胞和T细胞等多种炎性细胞参与的气道慢性炎症性疾病,并伴有气道高反应性、可逆性气流受限及黏液高分泌,其发病机制极为复杂,许多机制目前尚不很清楚。近来研究发现OX40/OX40L是哮喘免疫学发病机制中的一个重要环节,它在哮喘发病中的作用正逐渐被人们重视,现就OX40/OX40的生物学功能及调节作用以及其在哮喘治疗中的价值做一综述。
Bronchial asthma is a chronic airway inflammatory disease involving many inflammatory cells such as eosinophils, mast cells and T cells. It is accompanied by airway hyperresponsiveness, reversible airflow limitation and mucus hypersecretion. Its pathogenesis The mechanism is extremely complex and many mechanisms are not yet clear. Recent studies have found that OX40 / OX40L is an important part of the pathogenesis of asthma, and its role in the pathogenesis of asthma is gradually being taken seriously. Now, the biological function and regulation of OX40 / OX40 and its role in the treatment of asthma Make a summary of value.