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目的:观察中药甲苓饮治疗肝硬化腹水的药效,并探讨其作用机制。方法:采用50%CCl4植物油溶液加10%乙醇造模,制作大鼠肝硬化腹水模型,观察甲苓饮ig对模型大鼠一般表现、尿量、尿钠、肝功能、肝纤维化血清学指标、凝血酶原时间及肝组织病理学等方面的影响。结果:甲苓饮可以较好的改善肝硬化腹水模型大鼠的行为表现、可增加尿量、降低血钠和增加尿钠含量,有较好的改善肝功能、降低肝纤维化血清学指标、缩短凝血酶原时间及减轻肝组织病理损害的作用。结论:甲苓饮对肝硬化腹水模型大鼠有较好的改善症状、利尿、保肝、抗肝纤维化及改善凝血等治疗作用。
Objective: To observe the efficacy of traditional Chinese medicine Jia Ling Decoction in the treatment of ascites due to cirrhosis and to explore its mechanism. Methods: The ascites model of rats with cirrhosis was made by modeling with 50% CCl4 vegetable oil and 10% ethanol. The clinical manifestations, urinary output, urinary sodium, liver function, liver fibrosis serological parameters , Prothrombin time and liver histopathology and other aspects of the impact. Results: Jialing decoction could improve the behavior of rats with cirrhosis and ascites, increase urine output, lower serum sodium and increase urinary sodium, better improve liver function, lower serum fibrosis markers, Shorten the prothrombin time and reduce the pathological damage of liver tissue. Conclusion: Jialing decoction can improve symptoms, diuretic, protect the liver, anti-hepatic fibrosis and improve blood coagulation in rats with cirrhosis and ascites.