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为探讨幽门螺杆菌(Hp)感染后胃窦部内分泌G细胞 (分泌胃泌素 )、D细胞 (分泌生长抑素 )的变化 ,用免疫组织化学方法对4 0例慢性胃炎 (CG) (包括 10例为Hp阴性患者 )、4 0例活动期胃溃疡 (GU)和 4 5例活动期十二指肠球部溃疡 (DU)患者 (其中各包括 15例Hp阴性患者)的胃窦粘膜内G、D细胞进行标记后 ,运用医学图像分析系统对G、D细胞进行定量分析。结果显示 :Hp感染后 ,G细胞数目变化不大 (Ρ >0 0 5 ) ,但胞体灰度值增加(Ρ <0 0 5 ) ;D细胞数目减少 (Ρ <0 0 5 ) ,D细胞胞体灰度值无明显变化 ;各组G/D细胞数目比值有差异 (Ρ <0 0 1) ;Hp阳性的DU较GU组G细胞胞体灰度值增加 ,D细胞数目减少 ,差异有显著性意义 (Ρ <0 0 1) ,G/D细胞数目比值增大。本研究结果提示 ,Hp感染后胃窦部G、D细胞变化对某些疾病的发生发展起一定作用。
To investigate the changes of endocrine G cells (secreted gastrin) and D cells (secreted somatostatin) in the gastric antrum after Helicobacter pylori (Hp) infection, 40 chronic gastritis (CG) 10 cases of Hp-negative patients), 40 cases of active gastric ulcer (GU) and 45 cases of active duodenal ulcer (DU) patients (including 15 cases of Hp-negative patients each) in the antral mucosa G, D cells were labeled, the use of medical image analysis system for quantitative analysis of G, D cells. The results showed that the number of G cells did not change much after Hp infection (P> 0.05), but the gray value of cell body increased (P <0 05), the number of D cells decreased (P <0 05) The gray value had no significant change; the ratio of G / D cells in each group was different (P <0.01); the Hp-positive DU increased the gray value of G cells and the number of D cells in GU group, the difference was significant (P <0 0 1), the ratio of G / D cells increased. The results of this study suggest that the changes of G and D cells in gastric antrum after Hp infection play a role in the occurrence and development of certain diseases.