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本文目的是对比测定血浆肾素活性(PRA)及直接用放免法(IRMA)测定活性肾素,何者可作为测定充血性心衰患者肾素系统的方法。病人和方法是通过测量37例中到重度充血性心衰患者血浆肾素底物的浓度、PRA 和血浆活性肾素的浓度,来评价充血性心衰患者肾素血管紧张系统的状态。测定钠血症和心钠素(ANF)的血浆水平,作为心衰严重程度的生物学指标,利用前白蛋白和维生素 A 醇结合蛋白的浓度作为肝功能障碍的指标。结果;PRA 和活性肾素及心钠素的浓度在纽约心脏协会Ⅳ级心衰患者明显高於Ⅱ-Ⅲ级心衰患者,而钠血症和肾素底物、前白蛋白及维生素 A 醇结合蛋白的浓度在Ⅳ级心衰患者明显低於Ⅱ-Ⅲ级心
This article aims to compare the determination of plasma renin activity (PRA) and direct radioimmunoassay (IRMA) determination of active renin, which can be used as a method of determination of renin system in patients with congestive heart failure. Patients and Methods The renin-angiotensin system status was assessed in patients with congestive heart failure by measuring plasma renin substrate concentrations in 37 patients with moderate to severe congestive heart failure, PRA, and plasma concentrations of active renin. Plasma levels of natriuretic and atrial natriuretic factor (ANF) were measured as a biological indicator of the severity of heart failure using the concentrations of prealbumin and vitamin A alcohol binding protein as indicators of liver dysfunction. Results: The levels of PRA and active renin and atrial natriuretic peptide were significantly higher in class Ⅳ heart failure patients than in class Ⅱ-Ⅲ heart failure patients in New York Heart Association. However, the serum levels of PRA, renin, pro-albumin and vitamin A alcohol The concentration of binding protein in grade IV heart failure patients was significantly lower than the grade Ⅱ-Ⅲ heart